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Azathioprine

Catalog No. AAJ6231403
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Catalog No. AAJ6231403 Supplier Thermo Scientific Chemicals Supplier No. J6231403
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Description

CAS: 446-86-6 | C9H7N7O2S | 277.262 g/mol

Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a nucleic acid synthesis inhibitor. It has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in Dichloromethane and dimethyl sulfoxide.

Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.

Chemical Identifiers

CAS 446-86-6
Molecular Formula C9H7N7O2S
Molecular Weight (g/mol) 277.262
MDL Number MFCD00069203
InChI Key LMEKQMALGUDUQG-UHFFFAOYSA-N
Synonym azathioprine, azothioprine, imuran, azathioprin, azatioprin, azamun, azanin, imurel, ccucol, imurek
PubChem CID 2265
ChEBI CHEBI:2948
IUPAC Name 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]

Specifications

Color Yellow
Quantity 1 g
Merck Index 14,902
Solubility Information Soluble in Dichloromethane and dimethyl sulfoxide.
Formula Weight 277.26
Physical Form Crystalline Powder
Chemical Name or Material Azathioprine

Safety and Handling

Hazard Category H302-H315-H319-H335-H350
Hazard Statement GHS H Statement
H350-H302-H315-H319-H335
May cause cancer.
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
EINECSNumber 207-175-4
RTECSNumber UO8925000
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only