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thymidylate synthetase, Mouse, Clone: 3A1, Abnova™
Mouse monoclonal antibody raised against a partial recombinant TYMS.
Supplier: Abnova Corporation H00007298M01
Description
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq
Sequence: ANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCSpecifications
| thymidylate synthetase | |
| Monoclonal | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| BC013919 | |
| TYMS | |
| TYMS (AAH13919, 111 a.a. ∼ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody |
| ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot | |
| 3A1 | |
| Mouse monoclonal antibody raised against a partial recombinant TYMS. | |
| TYMS | |
| HsT422/MGC88736/TMS/TS/TSase | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| 7298 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| IgG1 κ |