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SOD1 Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA118275

Catalog No. 01-670-528



Description

Description

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3) (1). SOD1 is found in all eukaryotic species as a homodimeric 32kDa enzyme containing one each of Cu and Zn ion per subunit (2). The manganese containing 80kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain (3). SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways (4). SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor

PA1-18275 detects Superoxide Dismutase 1 from mouse and rat samples.PA1-18275 has been successfully used in Western blot procedures.The PA1-18275 immunogen is a synthetic peptide corresponding to residues A(24) S G E P V V L S G Q I T(36) of mouse superoxide dismutase (SOD1), conjugated to diphtheria toxoid.Reconstitute with 100 ul of distilled water.
Specifications

Specifications

SOD1
Polyclonal
whole serum with no preservative
P08228, P07632
SOD1, ALS, ALS1, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA
Rabbit
IgG
RUO
Antibody
Polyclonal
Mouse, Rat
Western Blot
Unconjugated
Sod1
Lyophilized
SOD1
Synthetic peptide corresponding to residues A(24) S G E P V V L S G Q I T(36) of mouse superoxide dismutase (SOD1).
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
20655, 24786
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