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SOD1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA118274

Catalog No. 01-670-527



Description

Description

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3) (1). SOD1 is found in all eukaryotic species as a homodimeric 32kDa enzyme containing one each of Cu and Zn ion per subunit (2). The manganese containing 80kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain (3). SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways (4). SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor

PA1-18274 detects Superoxide Dismutase 1 from human samples.PA1-18274 has been successfully used in Western blot procedures.The PA1-18274 immunogen is a synthetic peptide corresponding to residues E(24) S N G P V K V W G S I K(36) of human superoxide dismutase (SOD1), conjugated to diphtheria toxoid.After reconstitution keep aliquots at -20ºC for a higher stability, and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid freeze/thaw cycles.Reconstitute with 100 ul of distilled water.
Specifications

Specifications

SOD1
Polyclonal
whole serum with no preservative
P00441
SOD1, ALS, ALS1, Cu/Zn superoxide dismutase, Homodimer, Indophenoloxidase A, IPOA
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Western Blot
Unconjugated
SOD1
Lyophilized
SOD1
Synthetic peptide corresponding to residues E(24) S N G P V K V W G S I K(36) of human superoxide dismutase (SOD1).
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6647
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