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Sphingosine Kinase 2 Polyclonal Antibody, Invitrogen™


Sphingosine Kinase 2 Antibody, PA1-12720, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: ELISA, Western Blot.

Manufacturer: pierce biotechnology inc  PA112720

Catalog No. 01-674-850

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Description & Specifications

Specifications

Applications ELISA
Applications Western Blot
Formulation 10 Miniblots purified antibody in PBS and 0.08% sodium azide
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Quantity 10 Miniblots
Gene ID (Entrez) 54635, 56034, 79429
Species Reactivity Human, Mouse, Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Gene Symbols PDGFC
Gene Accession No. Q8CI19, Q9EQX6, Q9NRA1
Gene Alias C76851, MGC102297
Host Species Rabbit
Antigen Sphingosine Kinase 2
Immunogen Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.
Format Purified
Conjugate Unlabeled
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Isotype IgG

Sphingosine Kinase 2 Antibody, PA1-12720, from Invitrogen. Species Reactivity: Human, Mouse, Rat; Applications: ELISA, Western Blot.

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.
Formulation: 10 Miniblots purified antibody in PBS and 0.08% sodium azide
Synonyms: C76851, MGC102297
Uniprot Accession: Q8CI19, Q9EQX6, Q9NRA1
Entrez GeneID: 54635, 56034, 79429
Gene Symbol: PDGFC
A suggested positive control for this product is active recombinant sphingosine kinase enzyme.