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PDGF-C Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA112720

Catalog No. 01-674-850



Description

Description

A suggested positive control for this product is active recombit sphingosine kinase enzyme.

Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cellcell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
Specifications

Specifications

PDGF-C
Polyclonal
PBS with 0.08% sodium azide
Q9NRA1, Q8CI19, Q9EQX6
C76851, MGC102297
Rabbit
IgG
10 Miniblots
-20° C, Avoid Freeze/Thaw Cycles
Primary
54635, 56034, 79429
ELISA, Western Blot
Unconjugated
PDGFC
Liquid
PDGFC
Synthetic peptide corresponding to the C-terminal of Sphingosine Kinase 2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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