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SIAH1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA112863

Catalog No. 01-675-843



Description

Description

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.

A suggested positive control for this product is human brain lysate.
Specifications

Specifications

SIAH1
Polyclonal
PBS with 0.08% sodium azide
Q8IUQ4
HUMSIAH, Siah-1, Siah-1a, hSIAH1
Rabbit
IgG
50 μg
-80° C, Avoid Freeze/Thaw Cycles
Primary
6477
Western Blot
Unconjugated
SIAH1
Liquid
SIAH1
Synthetic peptide corresponding to human SIAH-1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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