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SIAH1, E3 Ubiquitin Ligase Polyclonal Antibody, Invitrogen™


SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12861, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Manufacturer: pierce biotechnology inc  PA112861

Catalog No. 01-675-841

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Description & Specifications

Specifications

Antigen SIAH1, E3 Ubiquitin Ligase
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Format Purified
Formulation 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Gene Accession No. Q8IUQ4
Gene Alias HUMSIAH, Siah-1, Siah-1a, hSIAH1
Gene Symbols SIAH1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to human SIAH-1.
Isotype IgG
Quantity 100μg
Species Reactivity Human
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 6477
Target Species Human

SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12861, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.