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SIAH1, E3 Ubiquitin Ligase Polyclonal Antibody, Invitrogen™


SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12861, from Invitrogen™. Species Reactivity: Human; Applications: Western Blot.

Manufacturer: pierce biotechnology inc  PA112861

Catalog No. 01-675-841

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Description & Specifications

Specifications

Formulation 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Gene ID (Entrez) 6477
Applications Western Blotting
Storage Requirements Avoid Freeze/Thaw Cycles
Species Reactivity Human
Gene Symbols SIAH1
Gene Accession No. Q8IUQ4
Gene Alias HUMSIAH, Siah-1, Siah-1a, hSIAH1
Immunogen Synthetic peptide corresponding to human SIAH-1.
Format Purified
Host Species Rabbit
Antigen SIAH1, E3 Ubiquitin Ligase
Primary or Secondary Primary
Conjugate Unlabeled
Cross Reactivity Human
Monoclonal or Polyclonal Polyclonal
Quantity 100μg
Isotype IgG

SIAH1, E3 Ubiquitin Ligase Antibody, PA1-12861, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.

Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human SIAH-1.
Formulation: 100μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: HUMSIAH, Siah-1, Siah-1a, hSIAH1
Uniprot Accession: Q8IUQ4
Entrez GeneID: 6477
Gene Symbol: SIAH1
A suggested positive control for this product is human brain lysate.