RIT1 Polyclonal Antibody, Invitrogen™

Description

RIT1 Antibody, PA1-12571, from Invitrogen. Species Reactivity: Human; Applications: Western Blot.

Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
Host Species: Rabbit
Cross Reactivity: Human
Isotype: IgG
Immunogen: His-tagged recombinant human Rit protein.
Formulation: 100μg purified antibody in PBS and 0.08% sodium azide
Synonyms: MGC125864, MGC125865, RIBB, RIT, ROC1
Uniprot Accession: Q92963
Entrez GeneID: 6016
Gene Symbol: RIT1
This product detects RIT1 in Human samples. This product has been successfully used in Western Blot procedures. The immunogen is His-tagged recombinant human Rit protein..

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