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RIT1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA112571

Catalog No. 01-674-798



Description

Description

Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
Specifications

Specifications

RIT1
Polyclonal
PBS with 0.08% sodium azide
Q92963
MGC125864, MGC125865, RIBB, RIT, ROC1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
6016
Western Blot
Unconjugated
RIT1
Liquid
RIT1
His-tagged recombit human Rit protein.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
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