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anti-Parkin Polyclonal, Thermo Scientific™

Parkin Polyclonal antibody PA1-18266 from Thermo Scientific™ specifically detects Parkin in Human and Rat samples, and it is validated for Immunohistochemistry and Western Blot

Manufacturer: pierce biotechnology inc  PA118266

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Catalog No. 01-670-519

 

Description & Specifications

Specifications

Antigen Parkin
Applications Immunohistochemistry
Applications Western Blotting
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rat
Format Serum
Formulation 100μL unpurified Antibody in whole serum, with no preservative;
Gene Accession No. O60260, Q9JK66
Gene Alias Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Gene Symbols PARK2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
Isotype IgG
Quantity 100μL
Species Reactivity Human, Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 5071, 56816

Parkin Polyclonal antibody PA1-18266 from Thermo Scientific™ specifically detects Parkin in Human and Rat samples, and it is validated for Immunohistochemistry and Western Blot

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Host Species: Rabbit
Cross Reactivity: Human, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin.
Formulation: 100μL Unpurified Antibody in whole serum, with no preservative
Synonyms: Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, Prkn, Park2
Uniprot Accession: O60260, Q9JK66
Entrez GeneID: 5071, 56816
Gene Symbol: PARK2
PA1-18266 detects Parkin from human and rat samples. PA1-18266 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18266 immunogen is a synthetic peptide corresponding to residues N S L I K E L H H F R I L G E E Q of human Parkin, conjugated to KLH. Reconstitute with 100 ul of distilled water.