NF-H Polyclonal Antibody, Invitrogen™

Description

PA1-10016 detects Neurofilament NF-H, primarily the hyperphosphorylated axonal form which yields a band at ∽200kDa in Western blot applications.

Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. The neurofilament (NF) triplet proteins (∽70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are normally restricted to neurons. The 70 kDa NF-protein can self-assemble into a filamentous structure, whereas the 160 kDa and 200 kDa NF-proteins require the presence of the 70 kDa NF-protein to co-assemble.