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NTN1 Rabbit anti-Bovine, Feline, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112869
Description
A suggested positive control for this product is MDCKII cell lysate.
Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.Specifications
NTN1 | |
Polyclonal | |
Unconjugated | |
NTN1 | |
Liquid | |
NTN1 | |
Synthetic peptide corresponding to human Netrin 1. | |
Ammonium sulfate precipitation | |
RUO | |
Antibody | |
Polyclonal | |
Bovine,Feline,Human,Mouse,Non-human primate,Rat |
Western Blot | |
1 mg/mL | |
PBS with 0.08% sodium azide | |
O95631, O09118, Q924Z9 | |
NTN1L | |
Rabbit | |
IgG | |
100 μg | |
-20° C, Avoid Freeze/Thaw Cycles | |
Primary | |
101082606, 114523, 18208, 522767, 9423 |