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anti-Netrin 1 Polyclonal, Thermo Scientific™

Netrin 1 Polyclonal Ab PA1-12869 from Thermo Scientific™ specifically detects Netrin 1 in Bv, Feline, Hu, Ms, Nhp and Rt samples, and it is validated for WB

Manufacturer: pierce biotechnology inc  PA112869

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Catalog No. 01-675-849

 

Description & Specifications

Specifications

Antigen Netrin 1
Applications Western Blotting
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Feline
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-Human Primate
Cross Reactivity Rat
Format Purified
Formulation 100μg purified Antibody (1mg/mL) in PBS, with 0.08% sodium azide;
Gene Accession No. O09118, O95631, Q924Z9
Gene Alias NTN1L
Gene Symbols NTN1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to human Netrin 1.
Isotype IgG
Quantity 100μg
Species Reactivity Bovine, Feline, Human, Mouse, Non-human primate, Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 101082606, 114523, 18208, 522767, 9423

Netrin 1 Polyclonal Ab PA1-12869 from Thermo Scientific™ specifically detects Netrin 1 in Bv, Feline, Hu, Ms, Nhp and Rt samples, and it is validated for WB

Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Host Species: Rabbit
Cross Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human Netrin 1.
Formulation: 100μg Purified Antibody (1mg/ml) in PBS, with 0.08% sodium azide
Synonyms: NTN1L
Uniprot Accession: O09118, O95631, Q924Z9
Entrez GeneID: 101082606, 114523, 18208, 522767, 9423
Gene Symbol: NTN1
A suggested positive control for this product is MDCKII cell lysate.