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NTN1 Rabbit anti-Bovine, Feline, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112869

Catalog No. 01-675-849



Description

Description

A suggested positive control for this product is MDCKII cell lysate.

Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Specifications

Specifications

NTN1
Polyclonal
Unconjugated
NTN1
Liquid
NTN1
Synthetic peptide corresponding to human Netrin 1.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Bovine,Feline,Human,Mouse,Non-human primate,Rat
Western Blot
1 mg/mL
PBS with 0.08% sodium azide
O95631, O09118, Q924Z9
NTN1L
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
101082606, 114523, 18208, 522767, 9423
SDS
Documents