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Netrin 1 Polyclonal Antibody, Invitrogen™


Netrin 1 Antibody, PA1-12866, from Invitrogen™. Species Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat; Applications: Western Blot.

Manufacturer: pierce biotechnology inc  PA112866

Catalog No. 01-675-846

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Description & Specifications

Specifications

Applications Western Blot
Formulation 25μg purified antibody (0.094mg/mL) in PBS and 0.08% sodium azide
Cross Reactivity Bovine
Cross Reactivity Feline
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-human primate
Cross Reactivity Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Gene Accession No. O09118, O95631, Q924Z9
Gene ID (Entrez) 101082606, 114523, 18208, 522767, 9423
Gene Symbols NTN1
Gene Alias NTN1L
Species Reactivity Bovine, Feline, Human, Mouse, Non-human primate, Rat
Isotype IgG
Quantity 25μg
Format Purified
Host Species Rabbit
Antigen Netrin 1
Conjugate Unlabeled
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Immunogen Synthetic peptide corresponding to human Netrin 1.

Netrin 1 Antibody, PA1-12866, from Invitrogen. Species Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat; Applications: Western Blot.

Netrin 1’s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
Host Species: Rabbit
Cross Reactivity: Bovine, Feline, Human, Mouse, Non-human primate, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human Netrin 1.
Formulation: 25μg purified antibody (0.094mg/mL) in PBS and 0.08% sodium azide
Synonyms: NTN1L
Uniprot Accession: O09118, O95631, Q924Z9
Entrez GeneID: 101082606, 114523, 18208, 522767, 9423
Gene Symbol: NTN1
A suggested positive control for this product is MDCKII cell lysate.