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NTN1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Invitrogen PA112866
Description
A suggested positive control for this product is MDCKII cell lysate.
Netrin 1âs main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.Specifications
| NTN1 | |
| Polyclonal | |
| Unconjugated | |
| NTN1 | |
| NTN1L | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 101082606, 114523, 18208, 522767, 9423 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.094 mg/mL | |
| PBS with 0.08% sodium azide | |
| O95631, O09118, Q924Z9 | |
| NTN1 | |
| Synthetic peptide corresponding to human Netrin 1. | |
| 25 μg | |
| Primary | |
| Bovine, Feline, Human, Mouse, Non-human Primate, Rat | |
| Antibody | |
| IgG |