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Myelin Basic Protein Polyclonal Antibody, Invitrogen™

Myelin Basic Protein Antibody, PA1-10008, from Invitrogen™. Species Reactivity: Bovine, Human, Mouse, Rat; Applications: ICC, IF, IHC, WB.

Manufacturer:  Pierce Biotechnology Inc PA110008

Catalog No. 01-670-265


 

Specifications

Description

Myelin Basic Protein Antibody, PA1-10008, from Invitrogen. Species Reactivity: Bovine, Human, Mouse, Rat; Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot.

Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago. The protein is made by oligodendrocytes in the central nervous system so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells. In the central nervous system there are three different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5 and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typical show two bands on Western blots, one at about 22kDa and another at about 18 kDa.
Host Species: Chicken
Cross Reactivity: Bovine, Human, Mouse, Rat
Isotype: IgY
Immunogen: Full length purified myelin basic protein isolated from cow nerve
Formulation: 100μL purified antibody in PBS and 10mM sodium azide
Synonyms: MGC99675, MBP
Uniprot Accession: P02686, P02687, P02688, P04370, P15720, P81558, P83487
Entrez GeneID: 100063306, 17196, 24547, 396217, 414286, 4155, 618684
Gene Symbol: MBP
In Western blot using rat spinal cord whole tissue homogenates, this antibody detects all isotypes of MPB, resulting in bands at ∽21.5kDa, 18.5kDa, 17kDa and 14kDa.
References:
Test: ICC, Dilution: 1:50, Species: Rt, Reference: Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+ channels. (Oct 2014) Dev. Growth Differ., Vol: 56, 8, 583-94, Teh DB,Ishizuka T,Yawo H; Pubmed ID: 25283796
Description & Specifications

Specifications

Myelin Basic Protein
Unlabeled
Purified
P02686, P02687, P02688, P04370, P15720, P81558, P83487
MBP
Full length purified myelin basic protein isolated from cow nerve
100μL
avoiding freeze/thaw cycles.
Polyclonal
Bovine,Human,Murine,Rat
Immunocytochemistry,Immunofluorescence,Immunohistochemistry,Western Blot
Bovine,Human,Mouse,Rat
100μL purified antibody in PBS and 10mM sodium azide
MGC99675, MBP
Chicken
IgY
Bovine, Human, Mouse, Rat
Primary
100063306, 17196, 24547, 396217, 414286, 4155, 618684
Promotions

Promotions

  • Purchase any three Invitrogen™ Antibodies and receive a fourth antibody at no additional cost. This is an NLSU exclusive offer. You must apply and qualify for the program to be eligible.

    06/30/18