Invitrogen™ Fibrinogen gamma Monoclonal Antibody (4H9)

Description

MA5-15906 targets FGG in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human samples. The MA5-15906 immunogen is purified recombinant fragment of human FGG expressed in E. Coli. . MA5-15906 detects FGG which has a predicted molecular weight of approximately 52kDa.

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.