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FADD, Mouse, Clone: 3C3, Abnova™
Mouse monoclonal antibody raised against a partial recombinant FADD.
Supplier: Abnova Corporation H00008772M02
Description
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq
Sequence: GKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEASSpecifications
| FADD, | |
| Monoclonal | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| BC000334 | |
| FADD | |
| FADD (AAH00334, 109 a.a. ∼ 208 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 λ |
| ELISA, Western Blot | |
| 3C3 | |
| Mouse monoclonal antibody raised against a partial recombinant FADD. | |
| FADD | |
| GIG3/MGC8528/MORT1 | |
| Mouse | |
| Affinity chromatography | |
| RUO | |
| 8772 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| Liquid |