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anti-Coronin 1a Polyclonal, Thermo Scientific™

Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

Manufacturer: pierce biotechnology inc  PA110022

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Catalog No. 01-670-279

 

Description & Specifications

Specifications

Antigen Coronin 1a
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry
Applications Western Blotting
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Serum
Formulation 100μL unpurified Antibody in whole serum, with no preservative;
Gene Accession No. O89053, P31146, Q91ZN1, Q92176
Gene Alias CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Gene Symbols CORO1A
Host Species Rabbit
Immunogen Full-length recombinant human Coronin 1a
Isotype IgG
Quantity 100μL
Species Reactivity Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat
Storage Requirements avoiding freeze/thaw cycles.
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 100064170, 100621483, 11151, 12721, 155151, 282196

Coronin 1a Polyclonal Ab PA1-10007 from Thermo Scientific™ specifically detects Coronin 1a in Hu, Ms and Rt samples, and it is validated for ICC, IF and WB

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Host Species: Rabbit
Cross Reactivity: Bovine, Chicken, Equine, Human, Mouse, Porcine, Rat
Isotype: IgG
Immunogen: Full-length recombinant human Coronin 1a
Formulation: 100μL Unpurified Antibody in whole serum, with no preservative
Synonyms: CLABP, CLIPINA, FLJ41407, HCORO1,mgC117380, TACO, p57
Uniprot Accession: O89053, P31146, Q91ZN1, Q92176
Entrez GeneID: 100064170, 100621483, 11151, 12721, 155151, 282196
Gene Symbol: CORO1A
This product detects Coronin 1a in Bovine, Chicken, Equine, Human, Mouse, Porcine and Rat samples. This product has been successfully used in Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot procedures. The immunogen is Full-length recombinant human Coronin 1a.