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Coronin 1A Rabbit anti-Bovine, Human, Mouse, Porcine, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA110022

Catalog No. 01-670-279



Description

Description

Highly conserved coronin family of proteins/actin regulators from WD-repeat superfamily were originally identified in Dictyostelium, wherein, coronin deletions were observed to affect actin-dependent processes, such as phagocytosis, cell motility, and cytokinesis. Coronin-1A (Coro1A) belongs to Type I coronins, almost exclusively expressed in hematopoietic lineages, and plays a key role during T lymphocyte activation, migration, survival, and calcium signaling. Moreover, Coronin-1A has been documented to be dispensable for actin-dependent functions in macrophages. Coro1a-deficient mice have reduced peripheral T cells due to both an impaired survival of naive cells and migrational defects. Both CD4+ and CD8+ T cell subsets are decreased in the periphery of Coro1a-/- mice while thymic cellularity and subpopulations are similar to those observed in wild-type mice. A nonsense mutation in Coro1a has been shown to protect against systemic lupus in a mouse model. Moreover, it has shown that Coro1a is mutated in a thymic egress-deficient mouse strain, but also in a patient with severe combined immunodeficiency (SCID).
Specifications

Specifications

Coronin 1a
Polyclonal
whole serum with no preservative
Q92176, P31146, O89053, Q91ZN1
CLABP, CLIPINA, FLJ41407, HCORO1, MGC117380, TACO, p57
Rabbit
IgG
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Porcine, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
CORO1A
Liquid
CORO1A
Full-length recombit human Coronin 1a
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
282196, 12721, 155151, 11151, 100621483
Documents