CNTF Polyclonal Antibody, Invitrogen™

Description

PA1-18365 detects CNTF from human, mouse, and rat samples. PA1-18365 has been successfully used in immunohistochemistry, Western blot, and ELISA procedures. The PA1-18365 immunogen is recombit human CNTF. Reconstitute with 100 µL of distilled water.

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. CNTF is a survival factor for various neuronal cell types, which seems to prevent the degeneration of motor axons after axotomy.