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BUB1B Polyclonal Antibody, Invitrogen™

BUB1B Antibody, PA1-12553, from Invitrogen™. Species Reactivity: Mouse; Applications: Immunohistochemistry, Western Blot.

Manufacturer:  Pierce Biotechnology Inc PA112553

Catalog No. 01-674-792


 

Specifications

Description

BUB1B Antibody, PA1-12553, from Invitrogen. Species Reactivity: Mouse; Applications: Immunohistochemistry, Western Blot.

Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Host Species: Sheep
Cross Reactivity: Mouse
Isotype: IgG
Immunogen: Recombinant protein corresponding to residues 232-603 of mouse Bub1b.
Formulation: 250μg purified antibody in PBS and 0.08% sodium azide
Synonyms: BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Uniprot Accession: Q9Z1S0
Entrez GeneID: 12236
Gene Symbol: BUB1B
A suggested positive control for this product is mitotic NIH-3T3 cells.
Description & Specifications

Specifications

BUB1B
Unlabeled
Purified
Q9Z1S0
BUB1B
Recombinant protein corresponding to residues 232-603 of mouse Bub1b.
250μg
Avoid Freeze/Thaw Cycles
Polyclonal
Murine
Immunohistochemistry,Western Blot
Mouse
250μg purified antibody in PBS and 0.08% sodium azide
BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Sheep
IgG
Mouse
Primary
12236
Promotions

Promotions

  • Purchase any three Invitrogen™ Antibodies and receive a fourth antibody at no additional cost. This is an NLSU exclusive offer. You must apply and qualify for the program to be eligible.

    06/30/18