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anti-BDNF Polyclonal, Thermo Scientific™


BDNF Polyclonal Ab PA1-18371 from Thermo Scientific™ specifically detects BDNF in Hu and Rt samples, and it is validated for ELISA, IHC and WB

Manufacturer: pierce biotechnology inc  PA118372

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Catalog No. 01-670-624

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Description & Specifications

Specifications

Antigen BDNF
Applications Enzyme Linked Immunosorbent Assay
Applications Immunohistochemistry
Applications Western Blot
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rat
Format Purified
Formulation 500μg purified antibody (1mg/mL) and no preservative
Gene Accession No. P23363, P23560
Gene Alias Brain-derived neurotrophic factor, Abrineurin
Gene Symbols BDNF
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF.
Isotype IgG
Quantity 500μg
Species Reactivity Human, Rat
Storage Requirements Avoid Freeze/Thaw Cycles
Primary or Secondary Primary
Monoclonal or Polyclonal Polyclonal
Gene ID (Entrez) 24225, 627

BDNF Polyclonal Ab PA1-18371 from Thermo Scientific™ specifically detects BDNF in Hu and Rt samples, and it is validated for ELISA, IHC and WB

BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Host Species: Rabbit
Cross Reactivity: Human, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF.
Formulation: 500μg purified antibody (1mg/mL) and no preservative
Synonyms: Brain-derived neurotrophic factor, Abrineurin
Uniprot Accession: P23363, P23560
Entrez GeneID: 24225, 627
Gene Symbol: BDNF
PA1-18372 detects BDNF from human and rat samples. This antibody cross-reacts with mouse NGF, recombinant human NT3, and NT4/5. PA1-18372 has been successfully used in immunohistochemistry, ELISA, and Western blot procedures. The PA1-18372 immunogen is a synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF, conjugated to KLH. Reconstitute with 500 ul of distilled water.