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BDNF Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Pierce Biotechnology Inc PA118371

Catalog No. 01-670-623



Description

Description

PA1-18371 detects BDNF from human and rat samples. PA1-18371 has been successfully used in immunohistochemistry, ELISA, and Western blot procedures. The PA1-18371 immunogen is a synthetic peptide corresponding to residues H(131) S D P A R R G E L(140) of mouse BDNF, conjugated to KLH. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles. Reconstitute with 100 μL of distilled water.

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer′s and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
Specifications

Specifications

BDNF
Polyclonal
whole serum with no preservative
P23560, P23363
BDNF
Synthetic peptide corresponding to residues H(131) S D P A R R G E L(140) of mouse BDNF.
RUO
24225, 627
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
ELISA, Western Blot
Unconjugated
BDNF
Brain-derived neurotrophic factor, Abrineurin
Rabbit
100 μL
Primary
Human, Rat
Antibody
IgG
SDS
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