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CRYAB Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Pierce Biotechnology Inc PA116950

Catalog No. 01-950-179



Description

Description

This Crystallin AB antibody is useful for Western blot analysis, where a band is seen at ∽20 kDa. There is also a band of greater intensity at ∽40 kDa that may be an aggregated heteromeric complex. CryAB aggregates with homologous proteins, including CryAA and the small heat shock protein HSP28, to form large heteromeric complexes.Suggested positive control: human and mouse skeletal muscle lysate, human skeletal muscle protein, antigen standard for HSPB1 (transient overexpression lysate), mouse skeletal muscle protein.

Crystallin AB (CryAB) is a developmentally regulated small heat shock protein known to protect cells from stress damage. It may also play an important role in the Golgi reorganization during cell division. CryAB is known to be associated with a number of neurodegenerative pathologies such as Alzheimer disease amd multiple sclerosis. As well, it has been found to be expressed in breast tumors of patients with shorter survival, suggesting that it may be a useful marker in identifying aggressive breast cancer.
Specifications

Specifications

CRYAB
Polyclonal
Unconjugated
CRYAB
Liquid
CRYAB
Synthetic peptide between amino acids 70-140 of the human Crystallin AB protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
1.08 mg/mL
tris citrate with 0.1% sodium azide; pH 7-8
P02511, P23927
Alpha crystallin B chain antibody, CryAB antibody, Alpha (B)-crystallin antibody, Rosenthal fiber componet antibody, Heat-shock protein beta-5 antibod
Rabbit
IgG
100 μL
4° C, do not freeze
Primary
12955, 1410
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