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activin A receptor, type IB, Mouse, Clone: 1C1, Abnova™
Mouse monoclonal antibody raised against a partial recombinant ACVR1B.
Supplier: Abnova Corporation H00000091M09
Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
Sequence: SGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVESpecifications
| activin A receptor, type IB | |
| Monoclonal | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| BC000254 | |
| ACVR1B | |
| ACVR1B (AAH00254, 24 a.a. ∼ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| 100 μg | |
| Kinases | |
| Primary | |
| Human | |
| Antibody |
| ELISA, In situ PLA, Western Blot | |
| 1C1 | |
| Mouse monoclonal antibody raised against a partial recombinant ACVR1B. | |
| ACVR1B | |
| ACTRIB/ACVRLK4/ALK4/SKR2 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Yes | |
| 91 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| IgG1 κ |