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Invitrogen™ Angiopoietin 2 Polyclonal Antibody
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Catalog No. PIPA527297
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100 μL
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Catalog No. Quantity
PIPA527297 100 μL
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Catalog No. PIPA527297 Supplier Invitrogen™ Supplier No. PA527297
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HUVEC. Predicted reactivity: Mouse (84%), Rat (86%), Dog (92%), Pig (92%), Chicken (85%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.

Specifications

Antigen Angiopoietin 2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene ANGPT2
Gene Accession No. O15123, O35462
Gene Alias AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand
Gene Symbols ANGPT2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Angiopoietin 2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 285, 89805
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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