Invitrogen™ Angiocidin Polyclonal Antibody

Description

Reconstitute at 0.2 mg/mL in sterile PBS.

Angiocidin, also known as thrombospondin-1 (TSP-1), is a multifunctional protein encoded by the THBS1 gene. It plays a critical role in various physiological and pathological processes, including angiogenesis, wound healing, and tumor progression. As an anti-angiogenic factor, angiocidin inhibits the formation of new blood vessels by binding to and regulating the activity of several cell surface receptors, such as CD36 and integrins. This function is crucial in maintaining tissue homeostasis and preventing the uncontrolled growth of blood vessels, which is a hallmark of cancer. Angiocidin also modulates cell adhesion, migration, and apoptosis, contributing to its role in tissue repair and immune response regulation. Elevated levels of angiocidin have been observed in various cancers, where it can influence tumor growth and metastasis. Additionally, it has been implicated in other diseases characterized by abnormal angiogenesis and inflammation, such as diabetic retinopathy and rheumatoid arthritis. Understanding the regulation and function of angiocidin is essential for developing therapeutic strategies aimed at modulating its activity to treat cancer and other angiogenesis-related diseases. Research into angiocidin offers valuable insights into its potential as a therapeutic target and biomarker for disease diagnosis and prognosis.