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Invitrogen™ AMPK alpha-2 Monoclonal Antibody (A6A10)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA542560
Description
Positive Control: Hela cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, PC-12 cell lysates, NIH/3T3, human kidney tissue, mouse brain tissue, rat kidney tissue. Subcellular Location: Nucleus, Cytoplasm.
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.Specifications
| AMPK alpha-2 | |
| Monoclonal | |
| 2 mg/mL | |
| TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
| P54646, Q09137, Q8BRK8 | |
| PRKAA2 | |
| Recombinant protein within human AMPK alpha 2 aa 231-430. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| A6A10 | |
| Unconjugated | |
| PRKAA2 | |
| 2310008I11Rik; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; A830082D05; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMPK; AMPK alpha 2; AMPK alpha-2 chain; AMPK subunit alpha-2; AMPK2; AMPKa2; AMPKalpha2; AMPK-alpha-2 chain; EC 2.7.11.1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; PRKAA; Prkaa2; protein kinase AMP-activated catalytic subunit alpha 2; protein kinase, AMP-activated, alpha 2 catalytic subunit | |
| Mouse | |
| Protein G | |
| RUO | |
| 108079, 5563, 78975 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |