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Amphotericin B, Streptomyces nodosus
Amphotericin B, CAS # 1397-89-3, is an antifungal that has been used against fungus caused by protozoan parasites of Leishmania genus. | CAS: 1397-89-3 | C47H73NO17 | 924.09 g/mol
$128.70 - $1567.59
Chemical Identifiers
| CAS | 1397-89-3 |
|---|---|
| Molecular Formula | C47H73NO17 |
| Molecular Weight (g/mol) | 924.09 |
| MDL Number | MFCD00877763 |
| InChI Key | APKFDSVGJQXUKY-ZNVUZQDLSA-N |
| PubChem CID | 134129663 |
| IUPAC Name | (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid |
| SMILES | C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ61491MC
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Thermo Scientific Chemicals
J61491MC |
100 mg |
Each for $128.70
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AAJ6149103
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Thermo Scientific Chemicals
J6149103 |
1 g |
Each for $372.48
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AAJ6149106
|
Thermo Scientific Chemicals
J6149106 |
5 g |
Each for $1,567.59
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Description
Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Amphotericin B is an antibiotic that has antifungal activity and is produced mainly by Streptomyces nodosus
Applications
- It has antifungal activity against fungus caused by protozoan parasites of Leishmania genus by binding to an essential component of the fungal cell membrane and altering cell membrane permeability
- It can suppress bone marrow progenitor cells and induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro
Chemical Identifiers
| 1397-89-3 | |
| 924.09 | |
| APKFDSVGJQXUKY-ZNVUZQDLSA-N | |
| (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid |
| C47H73NO17 | |
| MFCD00877763 | |
| 134129663 | |
| C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O |
Specifications
| Amphotericin B | |
| 1397-89-3 | |
| 100 mg | |
| C47H73NO17 | |
| 78342 | |
| Soluble in aqueous buffers at pH 2;0 or 11;0; Insoluble at pH 6;0-7;0; Also soluble in DMSO or DMF | |
| C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O | |
| 924.09 | |
| 924.1 |
| Powder | |
| Yellow | |
| Light and moisture sensitive | |
| MFCD00877763 | |
| 14,585 | |
| APKFDSVGJQXUKY-ZNVUZQDLSA-N | |
| (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid | |
| 134129663 | |
| Amphotericin B, Streptomyces nodosus |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
EINECSNumber : 215-742-2
RTECSNumber : BU2625000
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only