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Amiloride hydrochloride dihydrate

Catalog No. aaj6216806
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Quantity:
1 g
5 g
Catalog No. Quantity
AAJ6216806 5 g
AAJ6216803 1 g
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Catalog No. AAJ6216806

Supplier: Thermo Scientific Chemicals J6216806

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Description

Sodium channel blocker | CAS: 17440-83-4 | C6H13Cl2N7O3 | 302.116 g/mol

Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 ?M. Amiloride

  • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride • HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Solubility
Soluble in water at 50mg/ml

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Chemical Identifiers

CAS 17440-83-4
Molecular Formula C6H13Cl2N7O3
Molecular Weight (g/mol) 302.116
MDL Number MFCD00058197
InChI Key LTKVFMLMEYCWMK-UHFFFAOYSA-N
Synonym amiloride hydrochloride dihydrate, modamide, nirulid, amiloride hcl, amiloride hcl dihydrate, amilorid hydrochlorid-2-wasser, unii-fzj37245uc, amiloride hydrochloride usan:usp, amiloride dihydrate hydrochloride, n-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate
PubChem CID 68540
ChEBI CHEBI:2640
IUPAC Name 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Specifications

Melting Point >240°C
Color Yellow
Quantity 5 g
UN Number UN2811
Merck Index 14,406
Solubility Information Soluble in water at 50mg/ml
Formula Weight 266.09
Physical Form Powder
Chemical Name or Material Amiloride hydrochloride dihydrate

Safety and Handling

Hazard Category H301
Hazard Statement GHS H Statement
H301
Toxic if swallowed.
Precautionary Statement P264b-P270-P301+P310-P330-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber 217-958-2
RTECSNumber UQ2275500
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only