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Invitrogen™ AMID Polyclonal Antibody
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Catalog No. PA14345
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100 μg
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Catalog No. Quantity
PA14345 100 μg
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Catalog No. PA14345 Supplier Invitrogen™ Supplier No. PA14345

Description

Rabbit Polyclonal Antibody

PA1-4345 detects the human PRG3 protein in human samples. PA1-4345 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~41 kDa protein representing PRG3 in human heart lysate. The PA1-4345 immunizing peptide corresponds to amino acid residues residues 170-185 of the 41 kDa human PRG3 protein.

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.

Specifications

Antigen AMID
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene AIFM2
Gene Accession No. Q9BRQ8
Gene Alias 5430437E11Rik; AIFM2; Amid; apoptosis inducing factor, mitochondria associated 2; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated 2; apoptosis-inducing factor, mitochondrion-associated, 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; D730001I10Rik; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; PRG3; RP11-367H5.2
Gene Symbols AIFM2
Host Species Rabbit
Immunogen Synthetic peptide: V(170) T L I H S Q V A L A D K E L L(185).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84883
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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