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Invitrogen™ alpha Synuclein Polyclonal Antibody
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Catalog No. 01670509
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100 μg
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Catalog No. Quantity
01670509 100 μg
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Catalog No. 01670509 Supplier Invitrogen™ Supplier No. PA118256
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Description

Sheep Polyclonal Antibody

PA1-18256 detects alpha, beta, and gamma Synuclein from human and rat samples. Reconstitute with 100 μL of distilled water. After reconstitution, store aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Specifications

Antigen alpha Synuclein
Applications Immunohistochemistry (Frozen), Western Blot, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene SNCA
Gene Accession No. O55042, P37377, P37840
Gene Alias Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Gene Symbols SNCA
Host Species Sheep
Immunogen A synthetic peptide (AKEGVVAAAEKTKQGV) identical in human alpha, beta, and gamma synuclein conjugated to diphteria toxoid (aa 11-27).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20617, 29219, 6622
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Product Type Antibody
Form Lyophilized
Isotype IgG
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