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Invitrogen™ Human AKT1 (PKB alpha), His Tag Recombinant Protein
Description
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
Specifications
Specifications
| Accession Number | P31749 |
| Concentration | See Label |
| For Use With (Application) | Kinase Assay |
| Formulation | 20mM tris with 20% glycerol, 0.1mM sodium orthovanadate, 2mM DTT, 0.01% Triton X-100, 150mM NaCl, 0.5mM EDTA and no preservative; pH 7.5 |
| Gene ID (Entrez) | 207 |
| Molecular Weight (g/mol) | 59.1 kDa |
| Name | Human AKT1 (PKB alpha), His Tag |
| pH Range | 7.5 |
| Purification Method | Purified |
| Quantity | 10 μg |
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