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Invitrogen™ Adalimumab Chimeric Recombinant Mouse Monoclonal Antibody (D2E7 (Adalimumab))
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Catalog No. MA551684
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200 μg
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Catalog No. Quantity
MA551684 200 μg
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Catalog No. MA551684 Supplier Invitrogen™ Supplier No. MA551684
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Description

Mouse Recombinant Monoclonal Antibody

Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).

Adalimumab (Humira) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis. Adalimumab binds to the TNF alpha (tumor necrosis factor-alpha), and blocks its interaction with TNF alpha receptors, reducing the inflammatory response of autoimmune diseases.

Specifications

Antigen Adalimumab Chimeric
Applications ELISA, Inhibition Assays, Immunohistochemistry, Immunocytochemistry
Classification Recombinant Monoclonal
Clone D2E7 (Adalimumab)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias D2E7; Humira
Host Species Mouse
Immunogen This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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