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  7. 6(5H)-Phenanthridinone, 96%

6(5H)-Phenanthridinone, 96%

Catalog No. aab2518706
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Catalog No. AAB2518706 Supplier Thermo Scientific Chemicals Supplier No. B2518706
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Description

CAS: 1015-89-0 | C13H9NO | 195.221 g/mol

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Solubility
Soluble in DMSO (5 mg/ml). Insoluble in water.

Notes
Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Chemical Identifiers

CAS 1015-89-0
Molecular Formula C13H9NO
Molecular Weight (g/mol) 195.221
MDL Number MFCD00004988
InChI Key RZFVLEJOHSLEFR-UHFFFAOYSA-N
Synonym 6 5h-phenanthridinone, phenanthridin-6 5h-one, 6-phenanthridinol, phenanthridone, 6-5h-phenanthridinone, 6-phenanthridone, 6-phenanthridinone, 6 5h-phenanthridone, phenanthridin-6-ol, phenantridone
PubChem CID 1853
ChEBI CHEBI:75292
IUPAC Name 5H-phenanthridin-6-one
SMILES C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O

Specifications

Melting Point 288°C to 294°C
Quantity 5 g
Beilstein 140641
Solubility Information Soluble in DMSO (5mg/ml). Insoluble in water.
Formula Weight 195.22
Percent Purity 96%
Chemical Name or Material 6(5H)-Phenanthridinone

Safety and Handling

EINECSNumber 213-804-3
RTECSNumber SG0370000
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only