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  7. 5-Fluorouracil, 99%

5-Fluorouracil, 99%

Catalog No. AAA1345606
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25 g
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Catalog No. Quantity
AAA1345606 5 g
AAA1345614 25 g
AAA1345622 100 g
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Catalog No. AAA1345606

Supplier: Thermo Scientific Chemicals A1345606

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Description

CAS: 51-21-8 | C4H3FN2O2 | 130.08 g/mol

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Chemical Identifiers

CAS 51-21-8
Molecular Formula C4H3FN2O2
Molecular Weight (g/mol) 130.08
MDL Number MFCD00006018
InChI Key GHASVSINZRGABV-UHFFFAOYSA-N
Synonym 5-fluorouracil, fluorouracil, 5-fu, fluoroplex, adrucil, efudex, carac, fluracil, fluoroblastin, kecimeton
PubChem CID 3385
ChEBI CHEBI:46345
IUPAC Name 5-fluoro-1H-pyrimidine-2,4-dione
SMILES FC1=CNC(=O)NC1=O

Specifications

Melting Point ∽282°C (decomposition)
Assay Percent Range 99%
Quantity 5 g
UN Number UN2811
Beilstein 127172
Sensitivity Light sensitive
Merck Index 14,4181
Solubility Information Soluble in dimethylformamide,dimethyl sulfoxide,methanol,hot water,ammonium hydroxide,sodium hydroxide,ethanol and water.
Formula Weight 130.08
Percent Purity 99%
Chemical Name or Material 5-Fluorouracil
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Safety and Handling

Hazard Category H301-H312+H332-H315-H319-H335-H341-H361d
Hazard Statement GHS H Statement
H360-H341-H373-H302
Precautionary Statement P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P362-P501c
DOTInformation Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber 200-085-6
RTECSNumber YR0350000
TSCA Yes
storageNote1 Air Sensitive
Recommended Storage Ambient temperatures

RUO – Research Use Only