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4-(Chloromethyl)pyridine hydrochloride, 98%

Catalog No. p-7020788
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AAA1285906 5 g
AAA1285914 25 g
AAA1285922 100 g
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Catalog No. AAA1285906 Supplier Thermo Scientific Chemicals Supplier No. A1285906
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Description

CAS: 1822-51-1 | C6H7Cl2N | 164.029 g/mol

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar ′handle′ which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst™15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Solubility
Soluble in water (750 mg/ml at 20°C), soluble in 1N HCl (2.5%), DMSO, and methanol.

Notes
Hygroscopic. Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Chemical Identifiers

CAS 1822-51-1
Molecular Formula C6H7Cl2N
Molecular Weight (g/mol) 164.029
MDL Number MFCD00012826
InChI Key ZDHKVKPZQKYREU-UHFFFAOYSA-N
Synonym 4-chloromethyl pyridine hydrochloride, 4-picolyl chloride hydrochloride, 4-chloromethyl pyridinium chloride, 4-chloromethylpyridine hydrochloride, 4-chloromethyl-pyridine hydrochloride, ccris 1728, isonicotinyl chloride hydrochloride, pyridine, 4-chloromethyl-, hydrochloride, 4-chloromethyl pyridine hcl, 4-chloromethyl pyridine, chloride
PubChem CID 74570
IUPAC Name 4-(chloromethyl)pyridine;hydrochloride
SMILES C1=CN=CC=C1CCl.Cl

Specifications

Melting Point 166°C to 171°C
Quantity 5 g
UN Number UN3261
Beilstein 3689154
Sensitivity Hygroscopic
Solubility Information Soluble in water (750mg/ml at 20°C),soluble in 1N HCl (2.5%),DMSO,and methanol.
Formula Weight 164.04
Percent Purity 98%
Chemical Name or Material 4-(Chloromethyl)pyridine hydrochloride

Safety and Handling

Hazard Category H302-H314
Hazard Statement GHS H Statement
H301-H311-H314-H318-H317
Toxic if swallowed.
Toxic in contact with skin.
Causes severe skin burns and eye damage.
Causes serious eye damage.
May cause an allergic skin reaction.
Precautionary Statement P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c
DOTInformation Transport Hazard Class: 8; Packing Group: III; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.
EINECSNumber 217-350-7
TSCA No
Recommended Storage Ambient temperatures

RUO – Research Use Only