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2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine, 99%, Thermo Scientific Chemicals
$75.78 - $225.03
Chemical Identifiers
CAS | 145100-51-2 |
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Molecular Formula | C7H3ClF6N2O4S2 |
Molecular Weight (g/mol) | 392.671 |
MDL Number | MFCD00191833 |
InChI Key | TUFGVZMNGTYAQD-UHFFFAOYSA-N |
Synonym | 2-n,n-bis trifluoromethylsulphonyl amino-5-chloropyridine, 2-n,n-bis trifluoromethanesulfonyl amino-5-chloropyridine, comins' reagent, n-5-chloro-2-pyridyl triflimide, 2-n,n-bis trifluoromethylsulfonyl amino-5-chloropyridine, comins triflating reagent, n-5-chloro-2-pyridyl bis trifluoromethanesulfonimide, n-5-chloropyridin-2-yl-1,1,1-trifluoro-n-trifluoromethylsulfonyl methanesulfonamide, n-5-chloropyridin-2-yl triflimide, n-5-chloropyridin-2-yl-1,1,1-trifluoro-n-trifluoromethyl sulfonyl methanesulfonamide |
PubChem CID | 388544 |
IUPAC Name | N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide |
SMILES | C1=CC(=NC=C1Cl)N(S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F |
Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
AAL1692903
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Thermo Scientific Chemicals
L1692903 |
1 g |
Each for $75.78
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AAL1692906
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Thermo Scientific Chemicals
L1692906 |
5 g |
Each for $225.03
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Description
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.
Solubility
Reacts with water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under dry inert gas. It is sensitive to moisture.
Chemical Identifiers
145100-51-2 | |
392.671 | |
TUFGVZMNGTYAQD-UHFFFAOYSA-N | |
388544 | |
C1=CC(=NC=C1Cl)N(S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F |
C7H3ClF6N2O4S2 | |
MFCD00191833 | |
2-n,n-bis trifluoromethylsulphonyl amino-5-chloropyridine, 2-n,n-bis trifluoromethanesulfonyl amino-5-chloropyridine, comins' reagent, n-5-chloro-2-pyridyl triflimide, 2-n,n-bis trifluoromethylsulfonyl amino-5-chloropyridine, comins triflating reagent, n-5-chloro-2-pyridyl bis trifluoromethanesulfonimide, n-5-chloropyridin-2-yl-1,1,1-trifluoro-n-trifluoromethylsulfonyl methanesulfonamide, n-5-chloropyridin-2-yl triflimide, n-5-chloropyridin-2-yl-1,1,1-trifluoro-n-trifluoromethyl sulfonyl methanesulfonamide | |
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide |
Specifications
145100-51-2 | |
C7H3ClF6N2O4S2 | |
1 g | |
Moisture sensitive | |
Reacts with water. | |
C1=CC(=NC=C1Cl)N(S(=O)(=O)C(F)(F)F)S(=O)(=O)C(F)(F)F | |
392.671 | |
392.68 | |
2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine |
44°C to 47°C | |
MFCD00191833 | |
5833971 | |
2-n,n-bis trifluoromethylsulphonyl amino-5-chloropyridine, 2-n,n-bis trifluoromethanesulfonyl amino-5-chloropyridine, comins' reagent, n-5-chloro-2-pyridyl triflimide, 2-n,n-bis trifluoromethylsulfonyl amino-5-chloropyridine, comins triflating reagent, n-5-chloro-2-pyridyl bis trifluoromethanesulfonimide, n-5-chloropyridin-2-yl-1,1,1-trifluoro-n-trifluoromethylsulfonyl methanesulfonamide, n-5-chloropyridin-2-yl triflimide, n-5-chloropyridin-2-yl-1,1,1-trifluoro-n-trifluoromethyl sulfonyl methanesulfonamide | |
TUFGVZMNGTYAQD-UHFFFAOYSA-N | |
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide | |
388544 | |
99% |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
EINECSNumber : 000-000-0
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only