missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. 17-(Allylamino)-17-demethoxygeldanamycin, 99%

17-(Allylamino)-17-demethoxygeldanamycin, 99%

Catalog No. aaj66960ex3
Change view
Click to view available options
Quantity:
25 mg
100 mg
200 mg
Catalog No. Quantity
AAJ66960EX3 200 mg
AAJ66960MB 25 mg
AAJ66960MC 100 mg
3 options

Catalog No. AAJ66960EX3

Supplier: Thermo Scientific Chemicals J66960EX3

Only null left

Description

Possesses anti-tumor activity | CAS: 75747-14-7 | C31H43N3O8 | 585.698 g/mol

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Chemical Identifiers

CAS 75747-14-7
Molecular Formula C31H43N3O8
Molecular Weight (g/mol) 585.698
MDL Number MFCD04973892
InChI Key AYUNIORJHRXIBJ-MKJFUHJFSA-N
Synonym 17-aag
PubChem CID 133688938
IUPAC Name [(3S,5R,6S,7R,8Z,11R,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Specifications

Melting Point 207°C to 209°C
Flash Point >110°C (230°F)
Quantity 200 mg
Sensitivity Light sensitive
Solubility Information Soluble in DMSO at 150mg/mL; soluble in ethanol at 5mg/mL; Very poorly soluble in water
Formula Weight 585.69
Percent Purity 99%
Physical Form Solid
Chemical Name or Material 17-(Allylamino)-17-demethoxygeldanamycin

Safety and Handling

RTECSNumber LX8932000
TSCA No
storageNote1 -30° to -10°C
Recommended Storage Store at -20°C

RUO – Research Use Only