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  6. Invitrogen™ CD223 (LAG-3) Monoclonal Antibody (3DS223H), eFluor™ 506, eBioscience™, Invitrogen™

Invitrogen™ CD223 (LAG-3) Monoclonal Antibody (3DS223H), eFluor™ 506, eBioscience™, Invitrogen™

Catalog No. p-7193232
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69223941 25 Tests
69223942 100 Tests
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Catalog No. 69223941 Supplier Invitrogen™ Supplier No. 69223941
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Description

Mouse Monoclonal Antibody

LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.

Specifications

Antigen CD223 (LAG-3)
Applications Flow Cytometry
Classification Monoclonal
Clone 3DS223H
Concentration 5 μL/Test
Conjugate eFluor 506
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene LAG3
Gene Accession No. P18627
Gene Alias Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; FDC; LAG3; LAG-3; Ly66; lymphocyte activating 3; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG3; sLAG-3; soluble LAG 3lymphocyte activating 3; soluble LAG3
Gene Symbols LAG3
Host Species Mouse
Immunogen hCD223-FC PFA 4%.
Purification Method Affinity chromatography
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3902
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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