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1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals
1,1-Dimethylbiguanide hydrochloride (metformin hydrochloride, CAS # 115-70-4) is the salt of methylated biguanide, a compound exhibiting anti-hyperglycemic properties.
Supplier: Thermo Scientific Chemicals J6336114
Description
1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1
• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes
• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells
• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway
• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders
• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell
Specifications
| 1,1-Dimethylbiguanide hydrochloride | |
| 218°C to 226°C | |
| C4H12ClN5 | |
| MFCD00012582 | |
| 14,5938 | |
| Soluble in water (50mg/ml),ethanol,and DMSO (50 mM). | |
| [H+].[Cl-].CN(C)C(=N)N=C(N)N | |
| 165.63 | |
| 165.62 |
| 1115-70-4 | |
| White | |
| NH2C(=NH)NHC(=NH)N(CH3)2·HCl | |
| 25 g | |
| metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform | |
| OETHQSJEHLVLGH-UHFFFAOYSA-N | |
| hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride | |
| 14219 | |
| Powder |
Chemical Identifiers
| 1115-70-4 | |
| 165.63 | |
| OETHQSJEHLVLGH-UHFFFAOYSA-N | |
| 14219 | |
| [H+].[Cl-].CN(C)C(=N)N=C(N)N |
| C4H12ClN5 | |
| MFCD00012582 | |
| metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform | |
| hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride |
Safety and Handling
GHS H Statement
H302-H315-H319
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
H302-H315-H319-H335
EINECSNumber : 214-230-6
RTECSNumber : DU1800000
TSCA : No
Recommended Storage : Keep cold
RUO – Research Use Only