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Voriconazole, 98%, Thermo Scientific™
Voriconazole, CAS # 137234-62-9, is an antifungalagent that acts by inhibition of sterol biosynthesis.
Supplier: Thermo Scientific Chemicals 458670010
Description
This Thermo Scientific brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
Voriconazole is an antifungal compound that has activity against a wide variety of fungal species including Aspergillus and Candida
Voriconazole blocks sterol biosynthesis in Candida species through inhibition of CYP450-dependent 14-alpha sterol demethylase
It depletes the presence of ergosterol in the fungal cell membrane, which can lead to death or growth inhibition, depending on the organism
Applications
Voriconazole may be used in laboratory studies of drug safety, pharmacokinetics, and mechanism of action
Voriconazole has been used to inhibit CYP46A1 enzymatic activity in mouse neuroblasts
Voriconazole inhibits 24(S)-hydroxycholesterol in an ex vivo rat glaucoma model
Specifications
| Voriconazole | |
| Authentic | |
| 1g | |
| Solubility in water: insoluble in water. Other solubilities: soluble in methanol,acetonitrile | |
| CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O | |
| 349.317 | |
| CHEBI:10023 | |
| 98% |
| 137234-62-9 | |
| 0.5% max. | |
| C16H14F3N5O | |
| BCEHBSKCWLPMDN-MGPLVRAMSA-N | |
| (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol | |
| 71616 | |
| 349.31 |
Chemical Identifiers
| 137234-62-9 | |
| 349.317 | |
| 71616 | |
| (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
| C16H14F3N5O | |
| BCEHBSKCWLPMDN-MGPLVRAMSA-N | |
| CHEBI:10023 | |
| CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O |
Safety and Handling
GHS H Statement Toxic if swallowed. Suspected of causing cancer. May damage fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Harmful to aquatic life with long lasting effects.
GHS P Statement Wash face, hands and any exposed skin thoroughly after handling. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Obtain special instructions before use. Use personal protective equipment as required. Avoid release to the environment.
Danger
RUO â Research Use Only