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Thermo Scientific Chemicals U-73122, 95%
$75.58 - $414.16
Chemical Identifiers
| CAS | 112648-68-7 |
|---|---|
| Molecular Formula | C29H40N2O3 |
| Synonym | 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ62898LB0
|
Thermo Scientific Chemicals
J62898LB0 |
5 mg |
Each for $272.58
|
|
AAJ62898MA
|
Thermo Scientific Chemicals
J62898MA |
10 mg |
Each for $414.16
|
|
AAJ62898MCR
|
Thermo Scientific Chemicals
J62898MCR |
1 mg |
Each for $75.58
|
|
Description
It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors.Chemical Identifiers
| 112648-68-7 | |
| C29H40N2O3 | |
| 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione |
Specifications
| 5 mg | |
| Crystalline Solid | |
| 112648-68-7 | |
| 464.65g/mol | |
| Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml; May require heating or overnight mixing; Insoluble in water | |
| Crystalline solid |
| Off-white | |
| Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors | |
| C29H40N2O3 | |
| 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione | |
| Signal Transduction Reagent | |
| ≥99% |
Safety and Handling
Recommended Storage : Ambient temperatures
RUO â Research Use Only