missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Cell Analysis Products
  4. Cell Based Assays
  5. Signal Transduction Reagents and Kits
  6. Thermo Scientific Chemicals U-73122, 95%

Thermo Scientific Chemicals U-73122, 95%

Numéro de catalogue. AAJ62898LB0
Change view
Click to view available options
Quantity:
1 mg
5 mg
10 mg
3 product options available for selection
Product selection table with 3 available options. Use arrow keys to navigate and Enter or Space to select.
Numéro de catalogue. Quantity
AAJ62898LB0 5 mg
AAJ62898MA 10 mg
AAJ62898MCR 1 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 3 options available.
3 options
Numéro de catalogue. AAJ62898LB0 Fournisseur Thermo Scientific Chemicals Code fournisseur J62898LB0
Il en reste null

Description

It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors.

Identifiants chimiques

CAS 112648-68-7
Molecular Formula C29H40N2O3
Synonym 1-[6-[((17beta)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]pyrrole-2,5-dione

Spécifications

Quantity 5 mg
Description Off-white
For Use With (Application) Inhibitor of phospholipase C activation and inhibits the down regulation of muscarinic receptors
Formula Weight 464.65g/mol
Solubility Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml; May require heating or overnight mixing; Insoluble in water
Product Type Signal Transduction Reagent
Form Crystalline solid
InChI Key LUFAORPFSVMJIW-ZRJUGLEFSA-N
SMILES COC1=CC=C2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCC2=C1)NCCCCCCN1C(=O)C=CC1=O
IUPAC Name 1-(6-{[(1S,3aS,3bR,9bS,11aS)-7-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]amino}hexyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Molecular Weight (g/mol) 464.65
Assay ≥99%
Afficher plus de résultats Afficher moins de résultats

Sécurité et manipulation

Recommended Storage Ambient temperatures

RUO – Research Use Only