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Streptozotocin, MP Biomedicals™
Used in the treatment of pancreatic islet cell tumors. Streptozotocin, MP Biomedicals is a glucosamine-nitrosourea, a DNA-alkylating agent that enters cells via the GLUT2 glucose transport protein. It is used to treat malignant insulinoma and to induce Ty
Supplier: MP Biomedicals Inc 021005575
Description
Streptozocin is used to treat pancreatic islet cell tumors, including malignant insulinoma. It is also used to induce Type 1 diabetes in animals for medical research purposes.
- An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets
- Induces death of insulin-secreting cells, producing an animal model of diabetes
- Potent DNA methylating agent that induces chromosomal breakage
- Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter
Specifications
| Powder | |
| 121°C (decomposition) (literature) | |
| 500 mg | |
| N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozocin, STZ, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose | |
| ZSJLQEPLLKMAKR-UHEPRFFZSA-N | |
| 1-methyl-1-nitroso-3-[(2R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea | |
| 45357367 | |
| ∼75% α-anomer basis, ≥97% |
| 18883-66-4 | |
| EmM (228nm): 6.36 (ethanol) | |
| C8H15N3O7 | |
| Soluble in water (50mg/mL, clear to slightly hazy, light yellow solution) and ethanol. | |
| CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O | |
| 265.222 | |
| 265.22 |
Chemical Identifiers
| 18883-66-4 | |
| 265.222 | |
| N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozocin, STZ, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose | |
| 1-methyl-1-nitroso-3-[(2R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea |
| C8H15N3O7 | |
| ZSJLQEPLLKMAKR-UHEPRFFZSA-N | |
| 45357367 | |
| CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O |
Safety and Handling
Recommended Storage : −20°C, desiccate, store under nitrogen