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Rifabutin, 98%, Thermo Scientific Chemicals

Catalog No. AC461210010
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Quantity:
1 g
5 g
Catalog No. Quantity
AC461210010 1 g
AC461210050 5 g
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Catalog No. AC461210010

Supplier: Thermo Scientific Chemicals 461210010

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Description

Rifabutin, CAS # 72559-06-09, is a broad-spectrum antibiotic with activity against mycobacteria, gram-positive and gram-negative bacteria.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Rifabutin is a compound with antibacterial activity most commonly used against Mycobacterium tuberculosis
  • Rifabutin is a derivative of Rifamycin S that acts through blocking RNA polymerase subunit beta (RpoB)
  • Rifabutin is an inducer as well as a substrate of CYP3A, a cytochrome P450 enzyme

Applications

  • Rifabutin may be used in pharmacokinetic laboratory studies and high-throughput drug screens
  • May be used in laboratory studies to determine drug resistance mutations present in Mycobacterium tuberculosis strains

Chemical Identifiers

CAS 72559-06-9
Molecular Formula C46H62N4O11
Molecular Weight (g/mol) 847.02
MDL Number MFCD00866816
InChI Key ATEBXHFBFRCZMA-VXTBVIBXSA-N
Synonym rifabutin, ansamycin, rifabutine, mycobutin, ansatipine, ansatipin, alfacid, rifabutina, rifabutinum, antibiotic lm 427
PubChem CID 57448257
IUPAC Name (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1,3,5(31),9,19,21,25,29-octaen-13-yl acetate
SMILES CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(=O)C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC5(CCN(CC(C)C)CC5)N=C1C4=C3C2=O

Specifications

Assay Percent Range 97.5% min. (HPLC)
Packaging Glass Bottle
Quantity 1 g
Formula Weight 847
Percent Purity 98%
Chemical Name or Material Rifabutin

Safety and Handling

Hazard Category GHS Signal Word: Warning

RUO – Research Use Only