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Thermo Scientific™ Nitrocefin Disk

Numéro de catalogue. R211667
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Quantity:
25 Disks/Vial
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Numéro de catalogue. Quantity
R211667 25 Disks/Vial
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Numéro de catalogue. R211667 Fournisseur Thermo Scientific™ Code fournisseur RE211667
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Description

Nitrocefin-impregnated disk recommended for use in qualitative procedures for rapid detection of β-lactamase production by certain bacteria.

Detect β-lactamase production by Neisseria gonorrhoeae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus spp., Enteroccoccus spp., and anaerobic bacteria with Thermo Scientific™ Remel™ Nitrocefin Disk. The β-lactamase enzyme is produced by various organisms and is responsible for their resistance to penicillins and cephalosporins1,2. Since then, similar enzymes with somewhat different substrate specificities have been identified in various bacterial species. The test methods used to detect β-lactamase include iodometric, acidimetric, and chromogenic procedures3,4.

Since Abraham and Chain confirmed β-lactamase production by microorganisms to be responsible for antibiotic resistance, similar enzymes have been identified in various species. Some enzymes selectively hydrolyze penicillin class antibiotics (i.e., penicillinases), other enzymes hydrolyze all β-lactamase antibiotics except carbapenems (i.e. cephalosporinases) and some enzymes hydrolyze both5.

  • Ready to use - Nitrocefin impregnated disks.
  • Rapid results
  • Conforms to CLSI - Performance Standards for Antimicrobial Disk Susceptibility Tests – (Approved Standard M2-A8 and M11-A5)
  • Easy to interpret - With color change

The cephalosporin nitrocefin is the substrate used in this test. β-lactamase hydrolyzes the β-lactam ring of nitrocefin, producing cephalosporanic acid6. This results in the pale yellow nitrocefin changing to a pink product upon hydrolysis7. Aerobic and anaerobic β-lactamase-producing bacteria affect this color; organisms that fail to produce β-lactamase do not alter the pale-yellow color of nitrocefin within the time limits of test.

Spécifications

Content And Storage 2°C to 8°C
Description Nitrocefin Discs
CE Marker Yes
Detectable Analytes beta-lactamase (Haemophilus species, N. gonorrhoeae,Staphylococci)
Format Vial
Quantity 25 Disks/Vial