Genlantis™ PrimaPure™ Human Dermal Microvascular Endothelial Cells (HMVEC) and Kits

HMVEC are isolated from normal human neonatal foreskin or adult skin capillaries. They are cryopreserved at second passage and can be cultured and propagated at least 16 population doublings. They are responsive to cytokine stimulation in the expression of cell adhesion molecules. HMVEC express CD36 constitutively, while large vessel endothelial cells do not. HMVEC is an organ-specific endothelial cell system for the study of angiogenesis¹, tumor metastasis²,³, wound healing⁴, inflammation⁵,⁶, macromolecule transport⁷, and drug metabolism⁸. There is growing evidence of differences in physiology and pharmacology between microvascular endothelial cells and macrovascular endothelial cells⁹,¹⁰.

• Single donors to allow variability comparisons
• Each lot tested negative for HIV, Hepatitis B and C, mycoplasma, bacteria, yeast, and fungi
• Performance guaranteed with Genlantis media and reagents

1. Swerlick, R.A. et.al, J. Invest. Dermatol. 97(2):190 (1991).
2. Folkman, J. et al, Nature 288:551 (1980).
3. Lee, K.H. et al, J. Invest. Dermatol. 98(1):79 (1992).
4. Deryugina, E.I. et al, Hybridoma 15(4):279 (1996).
5. Sepp, N.T. et al, J. Invest. Dermatol. 104(2):277 (1995).
6. Swerlick, R.A. et al, J. Invest. Dermatol. 100(1):111S (1993).
7. Hanasaki, K. et al, J. Bio. Chem. 270(13):7533 (1995).
8. Pruckler, J.M. et al, Pathobiology 61:283 (1993).
9. Foster, C.A. et al, J. Dermatol. 21(11):847 (1994).
10. Schnitzer, J.E. et al, BBRC. 199(1):11 (1994).