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  7. Phorbol 12-myristate 13-acetate, 95%

Phorbol 12-myristate 13-acetate, 95%

Catalog No. p-7042831
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Catalog No. Quantity
AAJ63916MCR 1 mg
AAJ63916LB0 5 mg
AAJ63916MA 10 mg
AAJ63916MB 25 mg
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Catalog No. AAJ63916MCR

Supplier: Thermo Scientific Chemicals J63916MCR

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Description

Activates protein kinase C and promotes skin tumors in mice | CAS: 16561-29-8 | C36H56O8 | 616.84 g/mol

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Chemical Identifiers

CAS 16561-29-8
Molecular Formula C36H56O8
Molecular Weight (g/mol) 616.84
MDL Number MFCD00036736
InChI Key PHEDXBVPIONUQT-RGYGYFBISA-N
Synonym phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
PubChem CID 27924
ChEBI CHEBI:37537
IUPAC Name (1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,⁶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate
SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O

Specifications

Color White
Quantity 1 mg
Beilstein 2407201
Sensitivity Light sensitive
Merck Index 14,7332
Solubility Information Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water.
Formula Weight 616.83
Percent Purity >94%
Physical Form Film or Powder
Chemical Name or Material Phorbol 12-myristate 13-acetate

Safety and Handling

Hazard Category H315-H319-H335
Hazard Statement GHS H Statement
H315
Causes skin irritation.
Precautionary Statement P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
RTECSNumber QH4377000
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only