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Phorbol 12-myristate 13-acetate, 95%

Activates protein kinase C and promotes skin tumors in mice | CAS: 16561-29-8 | C36H56O8 | 616.84 g/mol

$220.66 - $1643.49

Chemical Identifiers

CAS	16561-29-8
Molecular Formula	C36H56O8
Molecular Weight (g/mol)	616.84
MDL Number	MFCD00036736
InChI Key	PHEDXBVPIONUQT-RGYGYFBISA-N
Synonym	phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
PubChem CID	27924
ChEBI	CHEBI:37537
IUPAC Name	(1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0Â²,â¶.0Â¹Â¹,Â¹Â³]pentadeca-3,8-dien-14-yl tetradecanoate
SMILES	CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O

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Products 4

Catalog Number	Mfr. No.	Quantity	Price	Quantity
Catalog Number	Mfr. No.	Quantity	Price	Quantity
AAJ63916MCR View Documents View Product Certificates	Thermo Scientific Chemicals J63916MCR	1 mg	Each for $220.66	Only null left	Sign In or Register to check your price and availability. Add to cart

AAJ63916LB0 View Documents View Product Certificates	Thermo Scientific Chemicals J63916LB0	5 mg	Each for $552.53	Only null left	Sign In or Register to check your price and availability. Add to cart

AAJ63916MA View Documents View Product Certificates	Thermo Scientific Chemicals J63916MA	10 mg	Each for $919.73	Only null left	Sign In or Register to check your price and availability. Add to cart

AAJ63916MB View Documents View Product Certificates	Thermo Scientific Chemicals J63916MB	25 mg	Each for $1,643.49	Only null left	Sign In or Register to check your price and availability. Add to cart

Description

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Specifications

Chemical Identifiers

CAS	16561-29-8
Molecular Weight (g/mol)	616.84
InChI Key	PHEDXBVPIONUQT-RGYGYFBISA-N
PubChem CID	27924
IUPAC Name	(1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0Â²,â¶.0Â¹Â¹,Â¹Â³]pentadeca-3,8-dien-14-yl tetradecanoate

Molecular Formula	C36H56O8
MDL Number	MFCD00036736
Synonym	phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
ChEBI	CHEBI:37537
SMILES	CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O

Specifications

CAS	16561-29-8
Molecular Formula	C36H56O8
Quantity	1 mg
Sensitivity	Light sensitive
Synonym	phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
InChI Key	PHEDXBVPIONUQT-RGYGYFBISA-N
IUPAC Name	(1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0Â²,â¶.0Â¹Â¹,Â¹Â³]pentadeca-3,8-dien-14-yl tetradecanoate
PubChem CID	27924
Formula Weight	616.83
Physical Form	Film or Powder

Color	White
MDL Number	MFCD00036736
Beilstein	2407201
Merck Index	14,7332
Solubility Information	Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water.
SMILES	CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O
Molecular Weight (g/mol)	616.84
ChEBI	CHEBI:37537
Percent Purity	>94%
Chemical Name or Material	Phorbol 12-myristate 13-acetate

Safety and Handling

GHS H Statement
H315
Causes skin irritation.

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

H315-H319-H335

RTECSNumber : QH4377000

TSCA : No

Recommended Storage : Store at -20°C

RUO – Research Use Only

Phorbol 12-myristate 13-acetate, 95%

Activates protein kinase C and promotes skin tumors in mice | CAS: 16561-29-8 | C36H56O8 | 616.84 g/mol

Chemical Identifiers

Description

Chemical Identifiers

Specifications

Safety and Handling

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