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Paromomycin sulfate
Inhibits initiation and elongation during protein synthesis | CAS: 1263-89-4 | C23H47N5O18S | 713.706 g/mol
Supplier: Thermo Scientific Chemicals J6127414
Description
Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsParomomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Solubility
Soluble in water
Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Specifications
| Paromomycin Sulfate | |
| Powder | |
| White | |
| +51° (c=5 in Water) | |
| MFCD00079278 | |
| 14,7041 | |
| LJRDOKAZOAKLDU-JXDXLELXSA-N | |
| (3S,5S,6S)-5-amino-2-(aminomethyl)-6-[(2R,4S,5S)-5-[(2R,5R,6R)-3,5-diamino-2-[(2S,3S,5S)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid | |
| 91972180 |
| Paromomycin sulfate | |
| 1263-89-4 | |
| 25 g | |
| C23H47N5O18S | |
| 5715182 | |
| Soluble in water | |
| C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O | |
| 713.706 | |
| 713.71 |
Chemical Identifiers
| 1263-89-4 | |
| 713.706 | |
| LJRDOKAZOAKLDU-JXDXLELXSA-N | |
| (3S,5S,6S)-5-amino-2-(aminomethyl)-6-[(2R,4S,5S)-5-[(2R,5R,6R)-3,5-diamino-2-[(2S,3S,5S)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid |
| C23H47N5O18S | |
| MFCD00079278 | |
| 91972180 | |
| C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P201-P202-P260-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
H315-H320-H335-H360
EINECSNumber : 215-031-7
RTECSNumber : WK2320000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only