Tunicamycin is a nucleoside antibiotic and an N-acetylglucosamine phosphotransferase inhibitor (Contessa et al.). It also inhibits protein palmitoylation (Patterson & Skene.). Tunicamycin can be used to induce the unfolded protein response and investigate the mechanism of autophagy (Ding et al.). CANCER RESEARCH· Radiosensitizes human pancreatic cancer cells to chemotherapy (Contessa et al.).· Induces endoplasmic reticulum stress and autophagy in cancer cells (Ding et al.).
