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Novobiocin Sodium Salt, MP Biomedicals™

Catalog No. MP215595701
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Catalog No. MP215595701 Supplier MP Biomedicals Inc Supplier No. 0215595701

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Description

Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:

  • For the production of positively supercoiled plasmid DNA
  • Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
  • Inhibitor of retrovirus RNA-dependent DNA-polymerase
  • To study heat shock protein inhibition

Chemical Identifiers

CAS 1476-53-5
Molecular Formula C31H35N2NaO11
Molecular Weight (g/mol) 634.61
MDL Number MFCD00066541,MFCD00066541
InChI Key AXOUUAINTJNFRS-UHFFFAOYNA-N
Synonym Albamycin, Cathomycin sodium
PubChem CID 131673945
SMILES [Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

Specifications

Physical Form Powder
Absorbance λ max: 307nm
Melting Point 220°C
Extinction Coefficient E1%= 600 (0.1M NAOH)
Potency ∼900μg/mg
Quantity 1 g
Optical Rotation −38.0° (2.5g/100ml ethanol at 24°C for the free acid)
Solubility Information Freely soluble in water (10%, clear, colorless solution)
IUPAC Name sodium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ide
Formula Weight 634.6

Safety and Handling

Recommended Storage Store at 2–8°C.