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Thermo Scientific Chemicals Mitoxantrone Dihydrochloride
CAS: 70476-82-3 | C22H30Cl2N4O6, C22H28N4O6.2HCl | 517.40 g/mol
Supplier: Thermo Scientific Chemicals J66341MF
Description
Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Specifications
| 50 mg | |
| -30°C to -10°C | |
| C22H30Cl2N4O6 | |
| 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride; | |
| Mitoxantrone dihydrochloride | |
| ZAHQPTJLOCWVPG-UHFFFAOYSA-N | |
| dihydrogen 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dichloride |
| Blue to black | |
| 70476-82-3 | |
| 517.40 | |
| Soluble to 5 mM in water and to 75 mM in DMSO | |
| Crystalline solid | |
| [H+].[H+].[Cl-].[Cl-].OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(O)C=CC(O)=C1C2=O | |
| 517.40 |
Chemical Identifiers
| 70476-82-3 | |
| 517.40 | |
| 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride; | |
| [H+].[H+].[Cl-].[Cl-].OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(O)C=CC(O)=C1C2=O |
| C22H30Cl2N4O6 | |
| ZAHQPTJLOCWVPG-UHFFFAOYSA-N | |
| dihydrogen 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dichloride |
Safety and Handling
EINECSNumber : 274-619-1
Recommended Storage : Store at -20°C
RUO – Research Use Only